This article collects evidence of the regeneration of new teeth that has been leaked to the media, as well as a general description of the methods that various authors offer in order to restore extracted and diseased teeth.

Here are a few short headlines from materials that testify to this phenomenon.

“... Mikhail, yesterday I watched a TV report about a grandmother who, at the age of 70, discovered that her teeth began to change for the third time in her life ...”

“... In a neighboring village, a healer teaches people to build up enamel on damaged teeth by rinsing their mouth with a solution of propolis and mentally imagining ...”.

“... The doctors of the Drozhzhanovskaya district hospital could not believe their eyes when their ward Maria Efimovna Vasilyeva opened her mouth wide. Wow - a 104-year-old resident of the village of Chuvashskoye Drozhzhanoye began to grow teeth again!

“... A 94-year-old resident of Cheboksary, Darya Andreeva, began to cut new teeth. According to specialists from the Chuvash republican dental clinic, now the old woman has already erupted one tooth.

“... A resident of the Sharanglu settlement in the Iranian province of East Azerbaijan has grown new teeth to replace those that have fallen out from old age.”

“... Unexpected happiness came to Marya Andreevna Tsapovalova, who lives in the Rehabilitation Center for Pensioners in Sochi. At a hundred years old, she suddenly began to grow new teeth!

“…One of them is 128-year-old Iranian Bahram Ismaili. From old age, he lost only three teeth, and new ones grew in their place. Bahram also does not eat meat. Besides, he had never brushed his teeth in his life.

A similar incident happened to the Indian peasant Baldev. He grew new teeth at the age of 110. Baldev is a heavy smoker. He complains that he has long been accustomed to holding the pipe with his toothless mouth and now it is inconvenient for him to clamp it with his teeth.

“... 12-year-old French girl Michelle is a little unlucky in life. The fact is that the girl suffers from a rare hereditary disease. Michelle has grown shark teeth that constantly break and grow back. She has much more of them than ordinary people, and they grow in several rows. Michelle recently had 28 teeth pulled out. And still she has 31 more of them than it should be.

Quote from an article by Natalia Adnoral:

The first miracle: caries may not be. A similar phenomenon was observed by Italian dentists who visited several monasteries in Tibet. Of the 150 monks examined, 70% did not have a single diseased tooth, while the rest had extremely limited caries. What is the reason? Partly - in the characteristics of nutrition. The traditional menu of Tibetan monks includes barley cakes, yak butter, Tibetan tea; in summer, turnips, potatoes, carrots, a little rice are added, sugar and meat are excluded.

And if caries has already damaged teeth?

Miracle two: caries can be reversed. An example of this is the cases of caries self-healing observed by dentists, when the affected tissues become strong again, and the restored part of the tooth acquires a darker shade. And such cases are by no means isolated. How does this happen? Builder cells detect damage and restore the integrity of the tooth in the same sequence in which it was originally created.

But what if caries won, and there was nothing left of the tooth?

Then prosthetics, of course.

Miracle three: new teeth can grow. This is called the "third change of teeth" and is observed in people of a very advanced age. And although a person does not have the rudiments of the third generation of teeth, there are remnants of “forever young” tissues that suddenly, for reasons that are not entirely clear, remember their purpose to become teeth and successfully realize their potential. Similar reports have recently been not uncommon: a 110-year-old resident of the Indian state of Uttar Pradesh has grown two new teeth; new teeth began to be cut in a 94-year-old resident of Cheboksary and a 104-year-old woman from Tatarstan; as many as six teeth appeared in an 85-year-old Novgorodian ... Of course, sensations can be treated with skepticism. If only... not the latest discoveries of science.

Scientifically proven miracle. A group of scientists from the American Research Center in Texas, led by Dr. McDougal, studied special cells that produce dental tissues (enamel and dentin). The genes responsible for this production are active only during the period of tooth formation, and then turn off. The scientists managed to “turn on” these genes again and grow a full-fledged tooth (while “in vitro”, outside the body). True, it is not necessary to count on early changes in the practice of prosthetics. It will take at least 20 years for the wide dissemination of the technology of growing one's own teeth ... "

A few more studies voiced by the media:

Researchers at Osaka University are preparing for human clinical trials. According to scientists, this method is much cheaper than prosthetics, ITAR-TASS reports.

The treatment system is based on the effect of genes that activate the growth of fibroblasts. It is the main cellular form of connective tissue.

Its action was tested on a dog that had previously developed a severe form of periodontal disease - atrophy of the tissues around the teeth, leading to their loss. Then the affected areas were treated with a substance containing the mentioned genes and agar-agar, an acidic mixture that provides a nutrient medium for cell reproduction. Six weeks later, the dog's fangs erupted. The same effect was observed in a monkey with teeth hewn to the ground.

Today, Paul Sharp from King's College London is engaged in the cultivation of teeth, he also heads the most famous company in this direction - Odontis - at Guys Hospital in the same London. In addition, the Forsyth Institute in Boston, USA and Queen Mary's College in the English city of Hants are working in this direction. Of our scientists, a Poltava geneticist from the Center for Transplantation of Cryopreserved Embryonic, Cellular and Fetoplacental Tissues Alexander Baranovich is working in this direction.

A few quotes:

A revolutionary method of growing teeth has been developed in Ukraine. The author of the idea is Alexander Baranovich, a geneticist at the Poltava Center for Transplantation of Cryopreserved Embryonic, Cellular and Fetoplacental Tissues.

He is working on a unique technique by which edentulous people can renew their jaw with little or no prosthetics. To do this, in place of the fallen tooth, an injection of a liquid based on the stem cells of the fallen out children's milk teeth is made into the patient's gum. Once in the jaw bone tissue, the cells begin to multiply, and a new tooth grows in 3-4 months.

According to the scientist, similar experiments are being carried out in the West. So, the English doctor Paul Sharp is close to creating a genetic gel with which a new tooth can be strictly programmed exactly for the shape and size that his predecessor had.

A team of researchers from the University of Oregon (USA) after a long search found the gene responsible for the production of tooth enamel, which is so necessary for teeth. It is the inability of enamel to recover that leads to tooth decay in more than 8/10 of the world's population. It is quite possible that scientists will be able to force the found gene to restore enamel, covering vulnerabilities. Thus, caries and some other dental diseases can be avoided.

Scientists have named a new type of gene Ctip2 - it is interesting that it is responsible not only for the production of enamel, but also for some of the functions of our immunity, the development of the skin and the nervous system. Now it is possible to attribute the restoration of enamel to this list of duties of this gene.

Japanese scientists from the Hokkaido Medical University managed to develop a unique technology for dental treatment thanks to a special chemical composition invented, which is based on collagen and phosphophorin proteins.

During the experiment, doctors placed a loose protein mass in a caries-damaged tooth of an experimental dog. In just two months, complete restoration of the dentin was recorded. Dentin is the substance that makes up the backbone of the tooth.

Japanese scientists intend to start human trials as soon as possible, while the practical application of the discovery will be possible in five years.

Scientists have managed to create a technology that allows you to grow new teeth in place of those that have fallen out. The miniature system stimulates the formation of dental tissue with the help of pulses of ultrasound and helps to heal diseased teeth, Eurekalert reports.

A small wireless device sealed in a biomaterial casing will not cause any inconvenience to the patient. It is attached in the oral cavity in any convenient way, for example, on "brackets" or in a removable crown. Scientists have also developed a sensor that changes the power of the device so that the pulses always reach the roots of the teeth. The researchers hope to have a finished model of the device by next year.

The device is intended for patients with root resorption, which occurs from mechanical or chemical damage. Mechanical damage can be caused by wearing corrective braces for a long time. The new device will allow such people to wear "brackets" and not worry about anything. It is estimated that among this segment of the population (five million people wear braces in North America), sales of the device will amount to 1.4 million copies.

Initially, the technology was tested on rabbits. The device also allows for bone growth in the jaw, which will greatly help children with hemifacial microsomia, a disease in which one side of the child's jaw remains underdeveloped in relation to the other. It is usually treated with surgery.

All dental restoration techniques from various authors have several common points, which are listed below:

1. Mental teleportation in time. Researchers recommend in their imagination, or in meditation, to be transported to the age of 13-15 years, when all the milk teeth are already gone, and the molars are still healthy. As best you can imagine yourself in this time, perhaps using photographs. Recall as many exciting moments from this period of life as possible ...

2. Work with the energy-information field. The goal is to implant or transfer the “embryo” of a healthy tooth to the place you need. According to Mikhail Stolbov - giving the order to the tooth to grow. Subsequently - a constant mental visualization of beautiful, shiny, white teeth.

3. Daily, according to some methods, hourly maximum attention to the right place, constant stimulation (both physical and psychological), increased blood flow, gum massage with a toothbrush, jaw training.

Reader comments:

2 years ago, a wisdom tooth was pulled out, an x-ray was taken, the gum was empty. A year later, he began to grow a tooth in the same place. Now I have grown more than half of the tooth. When I'm done, I'll move on to the rest. There is no secret here, our ancestors had it in the order of things. I know another person who has grown a tooth.
You don’t even need a practitioner, just trust yourself and believe in the result. Great placebo =) And various practices exist for this, to set you on the right wave.
Stepan Rudakov

About 15 years ago, on the people (Yandex sites), there was a forum dedicated to this issue, military pensioners, with bad scans of photos of their extended teeth, shared their experience, though they had salt + electricity there, with small currents, they thus welded their teeth, I don’t remember about the fortress, but they were definitely whiter in color than their relatives.
Alexander Dvornikov

Below is an excerpt from ]]> the unfinished book ]]> by Mikhail Stolbov (the author died in an accident), where Mikhail shares his experience of growing 17 new teeth.

It all started in 1978, when I was serving my three years of military service on Russian Island. It was then and there that almost all of my teeth were knocked out with a stool. Then I terribly hoped that they would immediately commission me, but false teeth were made for me at state expense within a week, and for the remaining 2.5 years, because of my burriness, I was “Mongrel” for everyone. Dentures are an unpleasant thing, but not fatal ... and they don’t get used to it.

Over the following years, I repeatedly changed these dental prostheses for new ones and already resigned myself to my fate, but some time ago I found myself “locked” in the Siberian taiga for almost a year. There I was overtaken by a disease, due to which I could not wear prostheses for more than 15-20 minutes a day. Any object and even my own language hurt me. Food had to be turned into porridge and swallowed without chewing. The process of eating turned into flour and dragged on for forty to sixty minutes. Besides, I couldn't talk! After all, teeth in commonwealth with the tongue are involved in the formation of sounds T, D, Z, N, R, C, C, H; and together with the lips in the formation of sounds V and F. Fortunately, at that time in the gatehouse near Razdolny I had no one to talk to ... But there was no one to save me either. I was very hurt and scared. This is what made me start looking for ways to GROW new teeth.

At the moment I have 17 (SEVENTEEN!!!) of my new teeth, which have grown contrary to all the statements of modern medicine. During this year, a lot of different events took place in the taiga, and I don’t know what specifically played a role in the occurrence of a miracle. Therefore, in my book I will try to carefully repeat the discoveries that I made in the taiga, and describe the actions that helped me become toothy again.

I will try to list them and list each one in sequence.
We change the worldview - we learn to believe in miracles
Quit smoking
Accumulate energy (lose excess weight)
Learn to listen to your body
Learn to listen to your soul
Learning to listen to the world
We grow teeth

A few letters:

“Hello Michael! Glad to have discovered your work on growing teeth on the internet. I have had all my teeth removed and recently discovered the growth of two new teeth. I can't explain the reason for this and so far I'm just watching the process ... I'm really looking forward to the end of your book. The teeth were completely removed a year and a half ago and these two teeth are growing IN NEW. I don’t have a serious methodology, with the exception of water charging and the “Chew-bite” exercise, and the formula “Where the thought goes, there is energy, where there is energy, there is blood.!
I'm 46 years old. Alexander".

“I grew two teeth. The essence of the results in motivation, at least for me it was. Initially, I just wanted to reanimate my teeth, in terms of aesthetics, but gradually I realized that they don’t react just like that. And it all started when the teeth became vital, they just began to fall out of the gums. Then the first results appeared. The pain was incredibly sharp, especially the first 2 days and when the gums broke through in some places. 2 teeth appeared, but not in place of the old ones, but nearby, though without curvature. In other words, the result is 2 new teeth and after six months of work there were no more results.»

“When my side tooth was pulled out, the front two teeth parted and a very wide and ugly gap turned out between them. Because of this, I was terribly worried and complexed. What was my surprise when, after some time, another tooth GROWN in this gap!!!”

“I would never have believed it! But, having found your articles on the net, I decided to try it, and three days ago I got a new tooth!!! I didn't understand anything at first! Something pricks the tongue and that's it. Yesterday I saw: crawling, infection!!!”

“Hi, Michael! I have one tooth with history. That is, I have had a cyst there for a long time, several years ago we intensively treated it. Today they took a picture, and it turned out that the bone tissue between the roots was restored, which, in principle, cannot be, as my dentist told me.

Forum quotes:

“Anatoly: I grew it purely consciously. He created a mental image of teeth where they no longer existed. In a couple of months, 4 beautiful white ones have grown, like snow. But our dentists are typical barbarians. They began to prove that this is an anomaly, that these are wisdom teeth (after 50 years) and before I had time to come to my senses, all 4 of my handsome men were brutally removed without anesthesia. A second attempt to grow new ones did not lead to anything. The fact is that I went to these barbarians to put up a bridge and they "proved" to me that these teeth would not only interfere, but also harm. And faith in Soviet medicine was higher than faith in one's own abilities, that's it ... "http://magov.net/blog/135.html

“It so happened that I dragged on with dental treatment to the last, always believing that I could do it on my own, and even it seems to me that it worked out once - I mentally “scanned” the jaws imagining how strength appears in the teeth and blood flow increases, but somehow it’s not systemic . And suddenly something appeared in the place of a tooth pulled out in the army. I didn't know what to think. On the one hand, the army could not completely remove the tooth and it could be the remnant of the root; on the other hand, what appeared was absolutely smooth and neat (!!!) Then suddenly a spot appeared on its surface (it protruded by 1-2 mm), which quickly began to turn into caries. And then, because of another tooth, my cheek swelled up and I had to go to the clinic where the doctor pulled out this piece along with the damaged tooth. Naturally, no one paid attention to all my attempts to pay attention to the fact that it might not be a fragment (and I was good too - under the injection, and even panicked by visiting the clinic - I was not particularly persistent). In short, after that event, about 4 years have passed and I gave up (there is nothing to chew on).
http://www.e-puzzle.ru/forum/lofiversion/index.php/t350.html

“And this is what one acquaintance told me, a former Khalulaev resident (one of the former special forces elites in Primorye). Somehow he met a Buddhist monk in the taiga, he was looking for herbs. got acquainted. He said that it is possible to grow teeth, for this you need a special attitude (possibly meditation), a certain set of herbs, and most importantly, you need to be in the taiga for three months. Apparently in nature it is necessary (not for everyone who wants to go to the Primorsky or Siberian taiga). Herbs, I think, are needed to cleanse the body, nature - to gain energy, meditation - for pure thoughts, mood - for the growth of teeth. http://forum.anastasia.ru/topic_21135_30.html

The fact of tooth growth officially recognized by medicine in place of the removed one:

For the first time in Moscow! Growing teeth from stem cells!!! August 27th, 2011

Frankly, I was very tired of this kind of sensations, periodically appearing even in very serious publications. And even more interesting are all kinds of conspiracy theories, such as: "Dentists deliberately slow down the introduction of growing teeth from stem cells, because they are afraid of being left without a job."
Excuse me, but if not dentists do this, then who will perform such procedures?

Let's take a sober look at the technology of "growing teeth" from stem cells and evaluate its prospects.

A little matan

Few people know that teeth are derivatives of epithelial tissues. Yes, teeth have a common origin with hair, nails and brains. Moreover, teeth are formed in a very, very specific way.

You know that a tooth is made up of hard and soft tissues. Soft tissue is the pulp, in other words, the “nerve”, which is located inside the tooth, in a special cavity. The pulp is of mesenchymal origin, in other words, it is formed from a completely different embryonic layer and has nothing to do with enamel or cementum.
The pulp contains odontoblast cells that form dentin, as well as blood vessels and nerve fibers that feed them.
While the formation of teeth occurs, odontoblasts produce the so-called. primary dentine. After teething, this process is very slow (secondary dentin is formed), and in case of any damage to the tooth, the response is the formation of tertiary dentin on the side of the damage.
In other words, dentin is capable of regeneration, since odontoblast cells remain throughout their lives in the pulp chamber.

The basis of the tooth, both in terms of volume and weight, is dentin. It is a porous hard tissue, something like a honeycomb structure, in the channels of which there are processes of odontoblasts. As soon as caries reaches the dentin, the infection spreads very, very quickly along these very dentinal tubules and inflammation occurs in the pulp of the tooth, which we call pulpitis. That is why the development of pulpitis DOES NOT ALWAYS require direct communication of the carious cavity with the pulp chamber of the tooth.

Tooth enamel is the hardest tissue in the human body. It is much harder than steel and experiences incomparable loads.
Enamel is formed by ameloblast cells, which, unlike odontoblasts, are present only during the period of tooth formation in the tooth germ, and disappear after tooth eruption.
That is why the enamel does not regenerate and is not restored when damaged (for example, during caries).
Tooth enamel from a microscopic point of view is very complex. It consists of three-dimensionally twisted so-called enamel prisms, the structure of which largely determines its strength and resistance to caries.
Enamel covers the crown part of the tooth, giving it a characteristic color and transparency. Therefore, the first sign of damage to the enamel, a violation of its structure, is a change in the color and transparency of the teeth.

The root of the tooth is covered with cement. Cement is harder than dentine, but much softer than enamel. Cement is formed during the period of tooth formation by cementoblast cells, a small amount of which remains in the periodontium even after teething. Cement, like enamel, is not capable of regeneration.
Periodontal fibers are woven into the cement of the root - very strong connective tissue ligaments, which, as it were, hang the tooth in the hole. In other words, a healthy tooth does not directly contact the bone at all.
The periodontium is needed to absorb the masticatory load, it also feeds the cementum of the tooth root.

Cementoblasts, like ameloblasts, are of epithelial origin.

Why am I telling you all this? To make it clear to you how complex each of your teeth is and how many tissues and cells are involved in its formation and development. Therefore, in order to recreate a full-fledged tooth from stem cells, we need to carry out the entire process of tooth formation in a test tube.

Now a little about stem cells.

Now even schoolchildren know that a stem cell is such a protocell from which any cell in the body can be obtained. And that our blood contains a certain amount of these same stem cells in a "sleeping" state.

That is, in order to grow something similar to an organ or tissue from stem cells, we need:

a) isolate the right amount of stem cells from the blood.
b) force the stem cell to differentiate in the right direction. In other words, something needs to be done so that when it divides, it turns into the cell we need - a hepatocyte, an osteoblast, an ameloblast, a neuron, etc.

And, if modern science more or less copes with the first task, then the second task is a serious problem.

Some time ago, mediators were discovered - special hormone-like substances that affect cell differentiation. Having processed the culture of stem cells with the necessary mediator, you can make it turn into liver, kidney or cartilage tissue - it all depends on which mediator is used.
So, our body consists of hundreds of different cells, and mediators are open only to some of them. For example, mediators are known that cause a stem cell to turn into a hepatocyte (the main tissue of the liver) or an erythrocyte.

There is another way to force stem cells to divide in the right direction. For example, plant a stem cell culture directly into an organ and wait to see what happens. It is on this method that the so-called. "stem cell therapy", which is now widely promoted in medicine. It is difficult to talk about the clinical and reliable effectiveness of such techniques, since it is still unclear whether anything, if anything, grows there.
Therefore, if you ever come across "cell therapy", especially in cosmetology - be careful. Well, we'll talk about this in a separate topic.

Let's get back to our sheep's teeth.

If we want to recreate a full-fledged tooth, we need to get the stem cells to divide in the right direction. So that they get:
1. Ameloblasts
2. Cementoblasts
3. Odontoblasts
4. Pulp fibroblasts, vascular cells, pulp nerve fibers
5. Periodontal fibroblasts

Moreover, our goal is not a shapeless cell culture. but the creation of an organ of a certain form.
In this regard, it is much easier to grow a liver or kidney from stem cells than a tooth. Since the shape of the liver, whether it is round or square, does not depend on its performance, while the functionality of the tooth is determined primarily by its shape.

And here comes another problem. All teeth (and there are thirty-two of them, if you remember) have a different shape, although they do not differ in cellular structure from each other. How to make a canine or a large molar out of a grown tooth? What determines its form and purpose? This question is still open and there is no unequivocal opinion on it.

Let us suppose, we managed to grow a tooth of the desired shape and size. And it's not just identical to a real tooth. He is alive! And now it needs to be transplanted into the place of the missing tooth.

For a while I did. That is, he transplanted eights to the place of the removed sixth teeth and watched what would come of it. You can read more about this. This technique has not received and will not receive clinical distribution (due to low clinical efficiency), so my work in this direction can be attributed more to science than to practice.

Also I often have to have . And I can say that even with a perfect match of the tooth to the hole, the engraftment process is not always successful. Although, sometimes.

It is clear that replanting a dislocated tooth or transplanting a wisdom tooth into a pre-prepared hole is much easier than integrating a tooth grown in a test tube. However, we still have not learned how to implant dislocated teeth with a 100% guarantee, not to mention the transplantation of our own teeth! What kind of implantation of artificially grown teeth can we talk about?

That is, even if all obstacles are overcome and we can grow teeth in a test tube, the problem of integrating these teeth into a living organism will remain unresolved.

HOWEVER, there is a way out. it is possible to transplant not a grown tooth, but, say, a tooth germ at an early stage. And then just wait until the tooth erupts. It seems like everything is very simple, but ... here, too, a number of unsolvable difficulties arise.
Firstly, it is not yet possible to stimulate the development of tooth germs and tooth growth. Research in this area is underway, but with varying success.
Secondly, the question of differentiation of the teeth themselves arises. It will be a shame if a wisdom tooth or something similar grows from a germ transplanted in place of a missing incisor.
Thirdly, how to organize the nutrition of the rudiments? Under natural conditions, their blood supply is provided by a network of thin vessels, which then turn into the neurovascular bundle of the pulp. How to do something like this is a very, very difficult question, unsolvable even in the foreseeable future.

Now periodically there are reports of teeth grown from stem cells that were successfully transplanted into the same mice. And it seems like these teeth even work ....
But ... there are several nuances that are not reported in the press, or are reported in passing.

Firstly, these most experimental teeth are grown on a ceramic matrix. This is how future teeth are differentiated and shaped.
Secondly, there is no tissue differentiation in these teeth. That is, they do not contain pulp, enamel, cement, etc. It is just a ceramic frame filled with fibroblasts. And they cannot be called full-fledged teeth.
Thirdly, the dentition of mice differs significantly from the dentoalveolar system of humans. At least by the fact that in rodents, teeth grow throughout their lives, and therefore their ability to regenerate and restore dental tissue is higher.
Fourth, there have been no reports of growing and transplanting functionally active teeth (those that are actually used in chewing), such as incisors, into rodents. Usually they try to grow and transplant molars, premolars, the functionality of which in mice (unlike humans) is not high.

Therefore, these technologies are not applicable in practical medicine and have applied scientific value.

Well and, the last - the price of a question.
I think it is unlikely that tooth growing will be in demand in general medical practice, if only because of the cost of the technology. See how much dental implantation costs now and how much work and time it takes. With stem cell teeth, everything will be much more complicated and expensive. And if now the cost of a dental implantation operation in Moscow is, on average, one thousand US dollars, then in our case, the cost of stem cell sampling alone will cost so much. And this, mind you, is the cheapest procedure at cost.

Therefore, growing teeth from stem cells, like radishes in the garden, is the fate of the far, far future. And even if such a technology becomes possible in about fifty or a hundred years, then we are unlikely to be able to afford teeth grown in a test tube, because their price will be very high.

So take care of what you have! And if something is missing, think about dental implants. The foreseeable dental future lies precisely in this promising direction.

Thank you for your attention.

Sincerely, Stanislav Vasiliev.

Growing new teeth- at least in three rows, if desired, is not far off. Scientists have discovered genes that are responsible for the formation of tooth enamel and the growth of whole teeth. And they could, at their discretion, either deprive animal teeth, or grow teeth anywhere.

Researchers from the University of Zurich (University of Zurich), led by Professor Timios Mitsiadis (Thimios Mitsiadis) found that the rudiment of the face and dental system is formed during fetal development from the epithelium and mesenchyme of the embryo. Violation of this process leads to the development of maxillofacial pathologies - defects in the development of teeth, cleft lip and cleft palate.

The scientists decided to conduct research on special transgenic mice in order to find out the pattern of temporal and spatial involvement of genes in the development of the dental system and face. And at the same time and accurately determine which genes are responsible for caries and the destruction of dental tissue.

toothless mice

For the experiment, the transcription factor of the Tbx 1 gene was artificially disrupted in experimental animals. The absence of this gene plays a fundamental role in the development of DiGeorge syndrome, in which a person develops a number of deformities of the heart, thymus, parathyroid gland, face and teeth. As well as tooth enamel, which the authors of the work call "the hardest organic tissue."

Tooth enamel, according to the researchers, is formed by the mineralization of certain proteins that are secreted by tooth epithelial cells - ameloblasts. These cells produce enamel until the tooth begins to erupt from the gum.

It turned out that mice with disabled Tbx 1 showed a lack of both enamel and ameloblasts. True, laboratory animals did not live very long, and scientists had to complete the experiment on long-lived tissue cultures, which made it possible to trace tooth growth until full maturity.

A link between enamel production and genes was also discovered by Mitsiadis' colleagues at the University of Oregon. True, according to them, the lack of enamel is affected by the shutdown of the transcription factor of another gene - Ctip 2.

stem cell teeth

The Zurich scientists also found that Tbx 1 is involved in the production of dental epithelial stem cells, which in turn form ameloblasts. Therefore, Mitsiadis believes that in some cases, stem cells can be used for restorative therapy for genetic anomalies of the teeth. “These cells may be useful for new transplantation technologies in the future,” the professor explains, “understanding the gene mechanisms that control the growth and restoration of teeth will allow us to produce new products and tissues to replace injured and diseased teeth. Although it is not worth betting only on stem cells.”

Mice with cleft palate and shark teeth

Researchers from the University of Rochester Medical Center, led by Dr. Rulang Jiang, decided not to dwell on the study of the origin of tooth enamel. They decided to find out how teeth grow on their own. And for this, they also turned to the period of face formation during the development of the fetus.

For science, laboratory mice again had to "suffer their teeth." Scientists have bred modified animals in which they “turned off” the Osr 2 gene, apparently a “colleague” of Tbx 1. Its “responsibility” included the prevention of tooth deformation and the appearance of a cleft palate, a birth defect in which the two halves of the palate do not connect, forming a gap.

"Knocking out" Osr 2 led to the fact that mice were born with a cleft palate. In addition, they grew teeth beyond the normal growth line. This fact interested Jang so much that he decided to leave the cleft palate alone for a while and focused on learning the ways teeth growth.

The first sign of tooth formation in mammalian embryos is the thickening of the epithelium along the jaw line. This suggests that a group of cells has formed, which is called the dental plate. Since all teeth subsequently form from this lamina, the scientists hypothesized that some special quality of the epithelial cells makes them suitable for this process. Previous studies have shown that teeth may have originated from epithelium that is not normally involved in the dental lamina. But how the signals for tooth growth appeared outside the boundaries of the dentition, scientists did not know.

Studies in other laboratories have also shown that the bone morphogenetic protein Bmp 4 is needed to initiate tooth growth. It has its own "signal enhancer" protein Msx 1. Therefore, Jang and colleagues suggested that there is some unknown factor that limited in mice with a deficiency Osr 2 tooth growth in one row, blocking Bmp 4.

Further research showed that the concentration of the active gene Osr 2 increases in the jaw rudiment in the direction from the cheek to the tongue. And the concentration of Bmp 4 increases in the opposite direction. Moreover, if Osr 2 does not work, then the activity of Bmp 4 extends beyond the dentition, and is not limited only to the dental plate. And then the teeth can grow far beyond the "traditional" dentition for mammals.

Where do teeth grow?

Again, Zhang did not stop there. He decided to find out why mammals have a gap between their teeth. And why sometimes it is not there and adjacent teeth look fused together. So the researchers revisited mice that had both the Osr 2 gene and the Msx 1 gene deleted.

Experimental mice lacking only Msx 1 failed to grow a single tooth. And for those who “turned off” both proteins, they grew only the first molars. The experiment allowed scientists to say that even if there is no Osr 2 that puts teeth in place, then the Bmp 4 protein is enough for something to grow in the mouth. But without Msx 1, the Bmp 4 signal did not increase enough to start the construction of the next tooth in the row.

Professor Zhang suggested that Bmp 4 works with other factors in tooth formation to help create a "demarcation zone" around each tooth where nothing can grow. When the tooth is nearly mature, Msx 1 reduces the growth inhibition level and development of the next tooth begins, driven by Bmp 4.

As they grow not only teeth, but also the jaw, each tooth must receive a signal that the jaw bone has already grown enough for it. Here, according to Zhang, lies the mechanism for the formation of the wolf's mouth.

The Rochester team plans to pinpoint the genetic circuit that controls tooth replication and palate development. Well, in order to keep up with colleagues from Zurich, to understand how stem cells can be used to treat the cleft palate. And growing teeth from scratch.

Materials about the difficult formation of teeth in their place can be read on the website of the University of Rochester Medical Center in the journal Science.

Teeth can now be grown in vitro

As the saying goes, teeth come with time. But soon, it seems, it will be possible to acquire not artificial teeth, but real ones. Only grown teeth in vitro. Japanese scientists told us about it.

Japanese scientists reported that they were able to replace a mouse tooth with one grown in a laboratory from cells and functioning similarly to the original.

For growing a full tooth scientists used primitive cells, which are somewhat higher than stem cells - mesenchymal and epithelial. An injection of cellular material was made into the collagen scaffold supporting the entire body.

After tooth cultivation they found that, about 1.3 millimeters long, it had matured into a mature form that consisted of complete parts such as dentin, pulp, vessels, periodontal tissues, and enamel. The scientists then removed the incisor of an eight-week-old mouse and implanted a grown tooth in its place. An examination conducted two weeks later showed that the new tooth was growing exactly like an ordinary one, it had taken root and functioned absolutely normally.

Growing a tooth was just the first step in the development of this revolutionary and promising technology.

Thus, the operation was the first successful experience of successfully replacing an entire organ with bioengineered materials. Researchers note that there are two ways tooth cultivation: either in organ culture or in a special capsule attached to the liver of another mouse. The growth process takes 14 days.

The method will allow whole organs to be grown from one or two cells, the researchers say, although they do not deny that they still have a lot of work to study this truly revolutionary achievement.

We all know that teeth a person grows twice during his life - dairy and permanent. Recently, however, there are more and more reports that some older people in the place of the removed or dropped out appear new white teeth.

Of course, this is not the norm, but scientists are interested in the phenomenon of natural regeneration of teeth and are actively looking for a mechanism in the human body that can start this process.

THIRD SHIFT

One day, a familiar prosthodontist told me that he made dentures for a woman of about 60 years old. Two weeks after the new teeth were safely installed, the patient returned to his office complaining of poor workmanship, as one of the artificial teeth had fallen out. What was the surprise of the doctor when, having taken an x-ray, he saw that the rudiments of a new tooth appeared in place of the extracted tooth, and they replaced the prosthesis!

At first, I was skeptical about his story, but then I found many similar stories on the Internet.

It turns out that the third change of teeth is observed quite often in older people. Scientists have found that the third generation of teeth is not initially programmed for anyone. But there are remnants of tissues that suddenly, for unknown reasons, are activated and become teeth.

A 110-year-old Indian has grown two new teeth, a 104-year-old resident of Chuvashia has begun to cut new teeth to replace those that have fallen out, an 85-year-old woman from Novgorod has as many as 6 new snow-white teeth. And this is a small fraction of such facts.

Such a sensation could not leave scientists all over the world indifferent.

The Texas Research Institute conducted a thorough study of the cells from which tooth enamel and dentin are built. Based on the research, it was concluded that a certain gene responsible for the formation of a tooth, after completing its mission, “turns off”.

Scientists managed to get this gene to work again, however, while outside the body. The studies were carried out on the teeth of mice. The result of the experiment was a new tooth 1.3 mm long, grown in a test tube. A new tooth was implanted in place of the removed one, and it must be said that it took root.

But in order to implement this technology into human life, it will take at least 20-30 years of hard scientific work.

NOT ONLY IN THE TEST TUBE

Loss of teeth is almost the most common problem of mankind, so many scientists around the world are working in this direction. One of the Poltava geneticists, A. Baranovich, proposed his own, one might say, revolutionary technology, which makes it possible to do without prosthetics.

The scientist was able to obtain stem cells from fallen baby teeth. The patient is asked to inject a liquid based on these cells into the gum at the site of the tooth that has fallen out. Once in place, the cells begin to actively divide and form a new tooth. The whole process takes 3-4 months. Unfortunately, the development of Baranovich has been suspended for the time being due to lack of funding.

English dentist P. Sharp has almost completed work on the creation of a genetic gel that will not only form a new tooth, but also give it the same shape and size as its predecessor.

Another interesting technology for growing teeth was reported by the American agency Eureka. Scientists have invented a miniature device that, using ultrasound, promotes the formation and development of dental tissue. The device itself is coated with biomaterials so as not to cause discomfort to the patient.

Attach it in the oral cavity with special brackets. The device has a sensor that allows you to change the power of exposure depending on the anatomical features of each patient. Tests of the technology on rabbits were successful. Presumably, the first finished model of the device will be presented within a year.

UNBELIEVABLE, BUT IT IS A FACT

Everything that has a material scientific basis is quite understandable. However, there are some methods of growing teeth that are hard to believe. Unfinished, due to the death of the author, the book of Mikhail Stolbov, an ordinary Russian person, became a real sensation, however, official medicine still refrains from commenting.

In 1978, Mikhail Stolbov served in the Soviet Army on Russky Island. As a result of rampant hazing in the unit, almost all of Mikhail's teeth were knocked out. Then, within a week, he was given the cheapest false teeth. In addition to being uncomfortable, they made the young man burr.

Then, from year to year, Stolbov changed the prostheses to new ones, but this did not help. By chance, the author of the book ended up in the Siberian taiga for almost a whole year. It was there, far from civilization and medicine, that he began to have inflammation of the oral cavity, accompanied by such pain that he not only could not wear prostheses, but touching the palate and gums of his own tongue caused unbearable suffering.

There was only ground food, the process of eating was delayed for an hour. On top of everything else, Mikhail practically could not talk, and, in fact, there was no one with anyone. Pain and fear served as a powerful incentive to find a way to grow new teeth. This fantastic idea turned into an obsession. In his book, Stolbov talks about what helped him grow 17 of his new teeth, awaken the regeneration process.

To begin with, the author recommends learning to believe in a miracle, and it does not matter that the impetus for this faith was pain, despair and fear. For him personally, the stimulus was the book "The Ancient Secret" - about a boy who was able to grow a leg. If a child did this, then he, an adult strong man, will also succeed. And Michael believed in a miracle.

The second stage should be the accumulation of energy, for this it is necessary to part with bad habits and excess weight. And then you need to learn to hear and perceive your body, soul and the world around you. All this together will help start the process of regeneration of teeth. You can treat Stolbov's story as a fiction, but the fact remains - 17 new teeth grown in the remote taiga.

REMEMBER EVERYTHING

Orlovsky poet, writer, yogi Sergey Veretennikov also believes that the teeth growth program can be launched with the power of thought.

To begin with, he recommends remembering the sensations that you experienced as a child when new teeth were cut. After all, a person remembers pain for a long time, if not forever. Itching in the gums, unpleasant swaying of milk teeth, and sometimes even the way a thread was tied to a milk tooth and pulled out.

These memories, according to Sergey, are the first "button" that should be pressed. The second “button” is located in the place of the lower front incisors, it is they who cut through the first in babies and are also the first to change to new ones. The third “button,” Veretennikov believes, is in our minds, and it must always be kept on.

Veretennikov's teeth growing technique consists of several stages. At first, you need to intensely imagine for about half an hour a day that under each tooth, small white seeds germinate inside the gums - the rudiments of new teeth. This is where childhood memories come in handy.

At the second stage, mental concentration is added to all this at a point located under the lower front incisors. And finally, the third stage will be concentration on the point between the eyebrows (third eye), but the first two concentrations must also be continued. The thought form should be something like this: "My teeth are completely renewed."

Sergey Veretennikov believes that by using this practice for a month, you can achieve results. The only thing that can interfere is the fear of losing old teeth and not growing new ones.

NO WARRANTY

The ability to regenerate teeth is undoubtedly a huge step forward in dentistry. But, even having learned to grow new teeth, scientists still face many problems. For example, the question remains how to make stem cells work simultaneously to create both hard tooth tissues (dentin, enamel) and soft tissues (pulp).

Besides, no one needs an arbitrary cell mass. You need a tooth of a specific size and shape, corresponding to its place in the mouth. Scientists believe that the experiment with mice may well have only a one-time positive result. And what will happen in the future, it is difficult to say.

The stimulation of growth and nutrition of new teeth remains in question. No one has yet figured out how to start this mechanism.

And finally, there is no guarantee that a new tooth will be successfully implanted, even if the fallen one is difficult to implant back. Again, not an adult tooth is transplanted, but its germ. And what will grow out of it, it is impossible to predict. Suddenly, an incisor will grow in place of the canine, or vice versa?

But, despite the difficulties, research continues. And perhaps our grandchildren will only know about prosthetics from books.

Galina MINNIKOVA

• In India, the girl had 202 teeth removed
• The boy suddenly began to grow a second row of teeth
• When teeth are out of place

paranormal-news.ru

The human body is unique and complex. Throughout life, we grow hair and nails, the cells of some organs are restored, for example, the stomach, skin, liver and even bones. But, I think, we all bitterly complained that one of the most important components of the body - the teeth - does not have the opportunity to be renewed. Yes, of course, bone formations unsuitable for life are being replaced by prostheses or implants today. However, they are incomparable with real teeth given to us by nature. Science comes to the aid of man, no matter how trite it may sound.

Each of us has gone through the stage of changing milk temporary teeth to permanent ones. After the loss of the first, their place is taken by the indigenous. Genetic scientists were interested in this process, and they started looking for a gene responsible for the growth and formation of dental tissue, as well as for stopping their development. If there were no such gene, then we would have not one dentition, but, like a shark, several interchangeable ones. Experimentally, geneticists managed to remove such a gene from mice. Experimental animals began to grow new teeth.

Today, this is probably one of the most discussed topics in the gene industry.

It is known that certain manipulations with stem cells make it possible to grow almost any organ. Cells extracted from gums or bone marrow can be used to create new teeth. The methods of "extracting" them are rather complicated and painful. Therefore, it is difficult to talk about the practical real growing of teeth from stem cells in the near future. However, the process has been launched, and in recent years, scientists have developed several ways to “program” stem cells, including a mechanism for restoring a formation that has lost its functionality:

The second is how to implant them in the patient's mouth. After all, it is necessary that they be accepted, taken root along with the real ones. Third, how new implants will be fed - this natural mechanism has not yet been fully understood.

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Is a test-tube tooth vital?

According to statistics, it is known that an adult during his life up to 50 years old may well lose eight or even more teeth. The main cause of tooth loss is caries, which, although it can be treated, sometimes the problem can only be solved by removing a tooth.

And then the only option to return the lost tooth is to resort to installing a prosthesis or implant. But both have their disadvantages, as they are not suitable for long-term use and may break down after several years of use.

What if you were offered to grow new teeth in a natural way instead of extracted teeth? It is clear that your natural teeth are much better than artificial ones.

Although the offer is quite tempting, but for the implementation of such an idea, it will have to wait several years, when the latest technology will be put into operation in clinics.

In the meantime, let's take a closer look at the method in order to know what can be expected in the near future.

How can new teeth be grown?

At this stage, more than one way to grow a tooth in a natural way has been developed. But unfortunately all this is still only in the initial development.

Although several experiments have already been carried out on growing teeth in an adult. There are many studies and attempts to grow a normal healthy tooth.

Most of the experiments carried out have given a positive result, but it will still be enough time before the technology is launched into free use in dental clinics.

The main methods of growing teeth, which are confirmed by research and positive practical results, are:

• change in genes;
• from stem cells;
• ultrasonic technology;
• laser correction.

Creating a tooth with changes at the gene level

All people in childhood lose milk teeth, which are replaced by permanent ones that remain with us until the end of life. But if a person loses any of his permanent teeth, he will not grow back.

Scientists also conducted studies during which they discovered the very human gene that is responsible for the change of teeth, while it prevents the formation of extra ones. If this gene were absent in the body, then a person would not have 32 teeth, but, like a shark, an infinite number.

In addition, in the course of experimental studies, it was found that when this gene was removed, new teeth grew in mice. Thus, it is possible to change this gene in humans, so that a new one grows in place of the extracted tooth.

Growing teeth with stem cells

Currently, the most discussed topic in genetic engineering is stem cells. Thanks to stem cells and some manipulations, almost any organ of the human body can be recreated.

To create any desired human tissue, stem cells can be manipulated with the necessary molecular information, that is, they can be transplanted to the right place. After the cells are transplanted to the place of the lost tooth, they are left alone, which gives time for the formation of a new tooth in the required size.

For this kind of experiment, stem cells from dental gums or bone marrow are excellent. As for the sensations that should arise during the process of forming a new tooth, this is a similar feeling experienced by everyone in childhood when cutting milk teeth.

Several experiments have already been carried out with positive results. Scientists have managed to achieve from stem cell transplantation the formation of a normal functioning tooth, no different from others.

That is, he, like others, had nerve endings, blood vessels, enamel and all other components of a standard tooth. So far, such an experiment has been carried out only on mice, and it may not be transferred to humans earlier than in 10 years. But scientists want to refine their methodology in the coming years.

Use of ultrasonic technology

Another way to grow new teeth for the third time is with ultrasound technology. Thanks to this innovative technology, a lost tooth can be painlessly restored.

This happens by transmitting an ultrasound device into the jaw of a person, at the place where a new tooth is needed. Such impulses stimulate the gums and jaw, which is why, in fact, a completely lost or injured tooth of an adult can be restored.

In other words, we can say that there is a massage of the necessary place of the gums. This method is the most original and has a huge potential that can amaze the world in the near future.

Laser correction

The last of the possible methods of naturally growing teeth is laser correction. In general, it seems that using a laser for growing teeth and restoring any part of the body is pure fantasy.

But experts are ready to prove the opposite, and moreover, they have already demonstrated how painless operations can be performed using a laser. Therefore, in the future, they plan to introduce laser technology into dentistry.

Scientists have tested this technology using various mammalian cells under a microscope. And each experiment showed the appearance of specific molecules that contain oxygen. This happened after laser radiation.

The molecules that appeared affected the stem cells, due to which the dental tissue was restored and a new one was formed. Scientists have seen how laser technology can trigger a regeneration process. Nobody has ever seen anything like this.

After such studies, scientists decided to conduct experiments on human stem cells of teeth. The result was the same as before. That is, lasers managed to activate stem cells, which in fact will make it possible to create various types of cells in large numbers.

Estimated prices

As for the prices for the future service of growing teeth in dental clinics, there is no exact data yet and one can only roughly assume that it will not be cheap. Apparently, not everyone will be able to use this service, since the new technology will not be available.

At the moment, only the cost of extracting stem cells is known, and it already exceeds the price of installing implants or dentures - and averages 1,000 euros.

That is why a person will have to pay about 3,000 euros for growing one tooth, including the price of an injection.

Summing up

Thus, soon all people will be able to finally get rid of dental implants and prostheses, if at least one of the methods of restoring the dentition goes beyond the scope of laboratory research.

Then scientists will be able to easily introduce new technologies to the market for open access, and in every dental clinic, anyone who has the right amount of money will be able to use this service.

Although growing teeth naturally will not be a cheap service, some people will still be able to take advantage of it. Technology does not stand still, but moves towards a person in order to improve his life.

dentazone.ru

The human body is unique and complex. Throughout life, we grow hair and nails, the cells of some organs are restored, for example, the stomach, skin, liver and even bones. But, I think, we all bitterly complained that one of the most important components of the body - the teeth - does not have the opportunity to be renewed. Yes, of course, bone formations unsuitable for life are being replaced by prostheses or implants today. However, they are incomparable with real teeth given to us by nature. Science comes to the aid of man, no matter how trite it may sound.

Scientists have calculated that in 50 years we lose about 8 teeth. The main reason for their loss is caries, most often leading to the removal of this hard formation. The delivered seals or prostheses do not differ in durability, and are amenable to destruction. It is quite another thing when a new tooth appears in place of the old one, white and beautiful. How to grow new teeth instead of extracted teeth? Such a problem is thoroughly dealt with by modern bioengineers, whose goal is to recreate the dental material. It is assumed that the technology of growing teeth in humans, the world will master in the near future. In the meantime, it is in the development stage. A number of technologies are being developed.

The following methods can boast of positive results:

Creating teeth by changing genes. Each of us has gone through the stage of changing milk temporary teeth to permanent ones. After the loss of the first, their place is taken by the indigenous. Genetic scientists were interested in this process, and they started looking for a gene responsible for the growth and formation of dental tissue, as well as for stopping their development. If there were no such gene, then we would have not one dentition, but, like a shark, several interchangeable ones. Experimentally, geneticists managed to remove such a gene from mice. Experimental animals began to grow new teeth.

Growing dental tissue using ultrasound. It is believed that this rather original method has great potential. Its essence is to apply ultrasonic pulses to a hollow place. Stimulation of the jaw and gums causes the formation of a new tooth to start.

Regeneration with a laser. The effect of laser radiation on stem cells made it possible to activate their growth, due to which the dental material begins to recover and a new one is formed.

Growing human teeth using stem cells. Today, this is probably one of the most discussed topics in the gene industry. It is known that certain manipulations with stem cells make it possible to grow almost any organ. Cells extracted from gums or bone marrow can be used to create new teeth. The methods of "extracting" them are rather complicated and painful. Therefore, it is difficult to talk about the practical real growing of teeth from stem cells in the near future. However, the process has been launched, and in recent years, scientists have developed several ways to “program” stem cells, including a mechanism for restoring a formation that has lost its functionality:

1. Interior. Based on the stem cells of milk teeth, they are placed in the desired cavity, where they, having begun to multiply, will create a new tooth in 2-3 months.
2. External. Reminds me of growing in a test tube. One of the first successful experiments was conducted by Japanese scientists who were able to replace a real organ with an artificial one. Special cells were taken. They were placed in a collagen scaffold, then transferred to an organ medium or a test tube capsule. In two weeks, a full-fledged formation was formed, structured from all the constituent tissues. The implant, placed in the oral cavity of the studied mouse, took root well and functioned well.

Despite the prospects, which gives dentists the opportunity to grow real teeth again, experts voice a number of related problems.
The first is how to make stem cells divide in different directions:

a) were of a certain shape and a specific size;
b) consisted of different dental "materials" (pulp, dentine, enamel, etc.).
The second is how to implant them in the patient's mouth. After all, it is necessary that they be accepted, taken root along with the real ones. Third, how new implants will be fed - this natural mechanism has not yet been fully understood.

Only the activity with which scientists are engaged in the development and introduction of the latest technologies inspires optimism. Therefore, all of humanity is looking forward to the moment when they learn how to grow teeth.

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The second change of teeth: the experience of centenarians

It turns out it's possible. Among the centenarians, those were found who acquired the third set of teeth without making any effort for this.

The first case was discovered in our country in the city of Sochi. In one of the rehabilitation centers for pensioners lives M. A. Tsapovalova, whose new teeth began to grow in the centennial anniversary year! This sensation aroused great interest of various specialists, including doctors. The woman herself says that this phenomenon is the result of a healthy lifestyle, complete cessation of smoking and alcohol, commitment to vegetarianism and the ability to quickly cope with stress.

Despite all its abnormality, this case is not the only one. Four more centenarians are known to have grown new teeth for the third time. At the age of 128, the Iranian Bahram Ismaily got three teeth in place of those that had fallen out. He is a vegetarian and, paradoxically, does not follow the rules of hygiene.

Another owner of new teeth lives in the Indian outback, cultivates the fields and smokes non-stop. His name is Baldev. The only problem for the 110-year-old peasant is that it has become unusual to clamp the pipe.

Our compatriots can also boast of new, grown teeth for the third time: Daria Andreeva (94 years old) from the city of Cheboksary and Marya Vasilyeva (104 years old) from Tatarstan.

All of these people had their teeth replaced for the third time. Scientists explain this phenomenon by the fact that even in people of senile age, cells of special tissues, similar to tooth germs, remain in the gums. At some point, under the influence of certain factors, they are activated, realizing their potential and purpose.

But how to grow whole teeth again, for the third time? This question has become very relevant for researchers. The result has been the development of a range of technologies that have made farming a reality. The main methods are based on changing genes, using stem cells, ultrasound and laser.

Working with genetic information

It is absolutely normal for a child to replace milk teeth with permanent teeth. But the loss of permanent teeth is definitive, with the exception of a few anomalous cases with centenarians. In the course of research, it was found that it is possible to change the genetic information in such a way that after the loss of a molar tooth, a new one grows in its place. However, the consequences of such an intervention have not been fully studied, therefore, its widespread introduction into practice should not be expected in the near future.

Another major study is being conducted by a group of specialists from a research center in the United States (Texas). The process is led by Dr. McDougal. Together with colleagues, he studied special cells that are involved in the production enamel and dentin. It was found that the gene responsible for this synthesis is active only during tooth formation. The researchers managed to take control of its functioning and grow a healthy tooth in the laboratory. According to forecasts, it will be possible to carry out such a procedure in the human body no earlier than in 20 years.

But scientists from Osaka University will soon be conducting human trials. The method is based on the effect of genes that activate the synthesis of fibroblasts, connective tissue cells. Research has already been done on dogs. The test animals were provoked by the development of periodontal disease, a disease in which the tissues surrounding the tooth atrophy and this leads to its loss. The gums of the dogs were treated with a preparation made from agar-agar, which served as a nutrient medium for the reproduction of tissues and genes responsible for the synthesis of fibroblasts. As a result, after a month and a half, the subjects had fangs. This effect was confirmed in an experiment with a monkey. According to the researchers, the method is more cost-effective than prosthetics.

Researchers at the University of Oregon in the United States, as a result of long work, have identified the gene responsible for the synthesis of enamel. It is unable to recover on its own, and its destruction leads to tooth loss in 80% of the world's population. Scientists plan to activate the gene in such a way that it restores enamel in vulnerable places. If this can be done, then it will be possible to forget about caries and a number of other diseases. This gene has already been given a name - Ctip2. It is responsible not only for enamel, but also for the functioning of the immune system, the formation of skin and nerve fibers.

Introduction of stem cells

Currently, genetic engineering is actively exploring the possibility of growing teeth from stem cells. With the help of certain manipulations, almost any organ or tissue in the human body can be created from them.
The technology for growing new teeth in humans is based on the use of stem cells that can be manipulated through certain molecular stimuli to create tooth tissues. Stimuli are made up of basic building blocks that create tissue and signaling molecules that stimulate and induce stem cells.

The resulting material is transplanted back to the same person, which ensures a minimal possibility of rejection. When the transplantation is completed, no further intervention is required: all that remains is to wait until the tooth grows completely. The necessary material is taken from the bone marrow and gums. The extraction procedure is still very painful. Scientists are working on improving the method of extracting stem material.

American specialists from the laboratory at the Massachusetts Hospital are working on the question of how healthy teeth can be grown for the third time. Based on the latest advances in genetics, they have grown artificial teeth "in vitro" using stem cells.

A geneticist from Ukraine Alexander Baranovich is developing a unique technique, using which people will be able to completely renew their jaws without resorting to a prosthetic procedure. To initiate growth in place of a lost tooth, a preparation based on stem cells from milk teeth is injected into the gum tissue. In the bone tissue, cells multiply rapidly, and after 3 months the result is visible.

Similar work is underway in the UK. Scientist Paul Sharp creates a genetic gel. With its help it will be possible to program the shape and size of the tooth. Thus, it will be completely identical to the lost one.

Exposure to ultrasound

The innovation and simplicity of this method is based on the use of low-intensity ultrasound pulses. During the growing process, ultrasonic equipment transmits impulses into the depth of the jaw and around it, stimulating the restoration of a diseased tooth or the growth of a new one to replace the lost one. In addition, the device builds up the jaw bone, so it can help patients with hemifacial microsomia, when one half of the jaw is noticeably underdeveloped compared to the other. Previously, such a disease required surgical intervention. And the principle of operation of ultrasound is similar to massage. The success of regeneration has been confirmed in experiments with rabbits, so it may soon be introduced into dental practice.

In Canada, tooth regeneration was made possible through the research of a dentist and two engineers. They created a low-intensity ultrasound device called LIPUS. The device looks like a pea, it is located on the root of the lost tooth and massages it with ultrasonic waves. The discovery is based on data obtained more than a decade ago. Then it was found that under the influence of low-intensity ultrasonic waves in mice, teeth quickly grow in place of the lost ones. Such an effect could be expected in humans. But still, the original goal was to strengthen the tissues under the destroyed or extracted tooth. The possibility of cultivation was a sensation.

So, researchers have created a technology that allows you to grow a new tooth in place of the fallen one. A very small device with the help of ultrasonic pulses stimulates tissue formation and accelerates the treatment of caries-damaged teeth. The device has no wire and is sealed in a case made of biological materials, thanks to which it is convenient to use and does not cause discomfort to the patient. In the oral cavity, it is fixed by any available method, it can be held on brackets or in a crown to be removed. In addition, scientists have created a sensor that changes device modes. The impulses adjust to the distance to the tooth root.

First of all, the device is intended for people with a partially destroyed tooth root due to mechanical or chemical effects. Mechanical injuries can be the result of long-term wearing of braces. The presented device allows these patients to wear braces and not worry about the integrity of the teeth.

For this achievement, the creators of LIPUS were presented with an award from the Canadian Council of Natural Sciences and Applied Disciplines. A team of researchers is finalizing the invention, after which it will be possible to begin industrial production of the device and its introduction into medical practice. To date, dental implants are the main way to restore the aesthetic appearance of a smile.

Using a laser

This technology is one of the latest developed, it involves the use of stem cells together with a laser.
low power. The idea belongs to a group of researchers from Harvard University. They used a focused laser beam to stimulate stem cells. It is assumed that induced by such way the stem material will lead to the formation of teeth. The technology is at the initial stage of development, it has not been tested on humans, and therefore it is too early to judge its effectiveness.

Progress in any of the scientific fields in the near future will make it possible to abandon surgical methods of treatment and prosthetics of teeth. To date, it is impossible to accurately answer the question of how to grow new teeth instead of extracted or damaged teeth. But while scientific research continues, traditional healers and yogis suggest trying to grow all the teeth using the power of consciousness.

Criticism of scientific methods

And yet, despite significant progress in cultivation, practitioners are very skeptical about the possible implementation of such methods in the clinical setting. Why? Their criticism is based on the following statements:

• When using stem cells, not a specific type of tooth is transplanted, but only a rudiment. It is impossible to say with certainty that it is the incisor that will grow in place of the incisor.
• There is no way to organize the division of stem cells in such a way that a tooth is formed, and not a biomass of dental cells.
• It is impossible to provide a germ in a test tube with good nutrition, the way it is obtained in its natural environment - in the gum.

All this confirms the fact that growing teeth with the help of science is the technology of the future. According to forecasts, bioimplantation technology will be introduced into practice no earlier than 2030. But if, nevertheless, the distribution of the method is successful, the procedure will be financially affordable for most people.

While scientists are trying to develop a method for implanting human germs, it is worth trying out mental techniques. All that is needed for their application is a great desire to have new healthy teeth and perseverance in striving for the goal. The main thing is not to overdo it and not forget about real life. Also, do not try to cure diseases only with the help of the power of the mind. Comprehensive treatment is the key to success.

mental techniques

Proponents of spiritual practices and practices of consciousness are of the opinion that it is possible to grow new healthy teeth with the power of thought. The nature of the human body is based on the renewal of teeth, as evidence of this is their change in childhood. You just need to start the same mechanism again. To do this, you need to be able to tell your body about the desire to have new teeth. Without the active work of consciousness, this ability will continue to sleep. In childhood, the change occurs in obedience to an automatic algorithm, and after that it is completed and can be launched using the work of the mind.

Our compatriot Mikhail Stolbov was engaged in the description of practical exercises for growing teeth. The general scheme of actions is as follows:

From the general provisions of the theory, Mikhail proceeds to a description of specific actions that will tell you how to grow new healthy teeth on your own, at home.

Practice at home

To grow new teeth, according to some authors, you can do it yourself, at home. The following exercises should be done daily:

The duration of the entire practical course should be at least a month if performed daily. Time frames are individual, for someone the result appears faster, for someone more slowly. The main criterion for success is the ability to feel your body, in particular, the jaws and teeth.

A common mistake leading to failure is clinging to negative thoughts, fear of losing old, diseased teeth. Doubts arise after several sessions, people begin to think: “Why do teeth not grow back for a long time?”, “Why are there no results?”. These thoughts firmly settle in the head and interfere with the launch of the mechanism for growing teeth.

In order to master the successful implementation of the practice, you need the following:

General mechanisms of mental practices

Growing teeth for the third time is possible. This fact has been proven by cases among centenarians and scientific research. The cultivation mechanism is embedded in the human body, the main task is to learn how to start it. There are many ways: changing information at the gene level, introducing stem cells, exposure to ultrasound, a laser beam, and mental techniques. To date, it is difficult to assess which of the methods will be more effective.

Dental repair Broken tooth and pain

Probably everyone has the thought of visiting the dentist. causes negative emotions. But modern medicine has found ways to make going to the dentist less unpleasant and more painless.

Many believe that the growth of teeth is limited to only two cycles: the growth of milk teeth, their loss and the growth of permanent ones. However, this is not at all the case, since in modern medicine artificial cultivation is also possible.

Growing new teeth: myth or reality?

Probably few people know, but with the help of scientists, it became possible to grow your own teeth. for the third and subsequent several times by artificial means.

Thanks to the discovery of Swiss scientists, a gene has been identified that responds to the health of dental tissues. This made it possible to use stem cells not only to treat various dental diseases, but also to recreate new ones. It is planned that with the help of these stem cells, the destroyed tooth will self-repair, and it will also be possible to avoid the occurrence of the cleft palate and cleft lip.

Currently there are several methods, with which you can grow new tooth germs: external, internal, with the help of a laser, ultrasound, mental technologies.

Ways of growing teeth: internal and external

It is clear that in a test tube it is allowed to recreate anything, including a tooth. Is it possible to recreate a new tooth in a person's mouth? One Ukrainian geneticist says yes. How this happens will be discussed below.

What is the internal method of recreating teeth? The scientist believes that it is necessary to administer injections based on stem cells of milk teeth in the place where this same clove grew. Such stem cells begin to multiply and, after a few months, a new tooth germ will grow. The question arises: where to get these stem cells? According to the scientist, it is rational to identify them from the fallen milk incisors.

So it's pretty simple recovery process a new tooth, but it takes time. Currently, developments in this area have been temporarily stopped due to lack of funds.

The external method consists in recreating a new tooth in the external environment. It can be an organ culture or a special test tube. Growing teeth was first tried on rodents.

This development was carried out by Japanese scientists. The essence of this external method was to use primitive cells that are higher than stem cells. The introduction of the material is possible in the framework of collagen, which is then placed in a test tube or organ culture.

The process of growing a new incisor took two weeks. It included all the necessary parts for its full growth. And he had dentin, pulp, vessels, necessary tissues and enamel. The artificial tooth germ took root well in rodents and functioned well in the future.

Problems of growing teeth artificially

Despite the fact that the possibility of recreating new teeth is a breakthrough in domestic medicine, scientists and geneticists note some difficulties and problems.

It is known that the goal of growing a tooth is to recreate a new organ, which must take the necessary shape. But how to make sure that the new organ does not turn into an amorphous piece? If mice managed to recreate a high-quality tooth, then no one can guarantee that the same thing will happen in humans.

To grow a full-fledged tooth germ, it is necessary to make sure that the stem cells begin to divide simultaneously and in different directions. Even if a new tooth is formed, then it is still necessary to qualitatively transplant it into the patient's mouth. Implanting a tooth correctly and making it take root is also not an easy task, and there is no guarantee.

Dentists, like no one else, understand that it is quite difficult to return a lost tooth to its place, it is almost impossible to do this. Also, the technique by which instead of extracted teeth are transplanted their own has not gained popularity precisely because of its low efficiency. Therefore, there is no guarantee that artificially created teeth will be able to take root in the patient's mouth with high quality.

Another point of contention is that not a tooth being transplanted, but only its germ, so it is not clear what will come of it in the future and whether it can become a full-fledged tooth. It is also necessary to stimulate the growth of this germ, otherwise it may stop in its development. Real teeth feed through their own channels, but how to make a similar mechanism in an artificial tooth is still a mystery.

The question of differentiation of teeth remains open. Where is the guarantee that a molar will not grow in place of the canine? Research in this area is ongoing, but no good results have been achieved so far.

Exposure to ultrasound

This method is based on the impact of ultrasound pulses. During growth, ultrasonic action transmits impulses to the jaw and stimulates the restoration of an old tooth or the growth of a new one. This affects the jaw bone. If earlier people who had one part of the jaw underdeveloped required surgical intervention, now they will be helped by ultrasonic treatment. This the principle is similar to massage.

Experiments with ultrasonic pulses were carried out on rabbits. Perhaps, after some time, such a technique will be introduced into the practice of medicine.

In Canada, a special apparatus with ultrasound has been created, similar to a small pea. It is introduced into the root of a fallen tooth and massages it with the help of ultrasonic pulses. Such an experiment was carried out on rodents and soon a new tooth grew. But the main purpose of this experience was to strengthen the tissues under the lost tooth. And the fact that a new tooth grew turned out to be a real sensation.

This device is closed in a case made of biological material and does not bring any discomfort to the patient. Of course, this method, first of all, is able to help people with incompletely decayed teeth.

For the invention of such a device, the inventors were awarded an award by the Canadian Council. Creators to this day improve this device with the aim of introducing it into medical practice as soon as possible.

Professor Jeremy Mao developed a procedure for recreating a tooth germ right in the alveolus. From natural materials, the professor built a frame that was no different from a real tooth and introduced a growth stimulator there. The experiment was carried out on animals in which this prong was introduced into an empty alveolus. And, after a couple of months, a newly made tooth germ grew in the animals, which ideally took root in the oral cavity and worked well in the future.

Laser and mental technologies

The method of using a laser to recreate a new tooth germ has been created relatively recently. Its essence lies in the use of stem cells simultaneously with a low-power laser. This idea was developed Harvard researchers. It is in its early stages. Since it has not been tested in humans, it is therefore not advisable to talk about it as an established technology.

While researchers are puzzling over how to master the technology that will effectively grow new teeth and introduce them into the patient's cavity, traditional healers recommend achieving this effect using the power of thought. No more, no less!

Nature laid the change of teeth in humans. The proof of this is the milk teeth, which are replaced by the usual ones. Healers and yogis believe that this renewal mechanism can be started again with the power of thought, one has only to inform one's body of this desire. But then painstaking work on yourself and your consciousness will follow.

Mikhail Stolbov described the algorithm of actions for recreating new teeth with the power of thought. This thought algorithm operates as follows:

• You should remember the feelings that a child had when his milk teeth fell out and new ones grew. It is important to remember more of these moments associated with tooth loss, pain and so on. This gives an impulse to renew consciousness.
• Next, it should be remembered that the incisors appear first, they are the first to fall out. Therefore, the recovery mechanism should begin with the incisors.
• These thoughts should arise in a person not only when he thinks about it, but always, for 24 hours a day, regardless of other thoughts of a person.

Then you need to move on to practice. Practical exercises for which you need to spend about 30 minutes:

The duration of these exercises depends on their regularity and on the characteristics of the human body. It is advisable to repeat the exercises every day for a month. For some, the result will be faster, while for someone it will be slower.

The main mistake of this method is that a person begins to have negative thoughts from the fact that the teeth begin to fall out, pain and discomfort arise. Such thoughts should be immediately discarded and directed in the right direction.

In order for these exercises are beneficial, some more conditions must be met:

Not only Stolbov was engaged in such mental techniques, but all such authors have a common mechanism for influencing the teeth:

1. Time travel. It is necessary to return to childhood and remember how the loosening of teeth and the growth of new ones took place, to return the sensations that were experienced during this period.
2. Changing the energy field and directing it to the right place.
3. It is necessary to constantly pay attention to such exercises, it is better not even once a day. And then the result will definitely not pass by.
4. It is necessary to start visualization from the incisors and move to the periphery.

Prices

Many people are concerned about this issue in the first place. There is no unequivocal and specific answer to it, since this method has not yet gained its popularity.

But still it is planned that prices will not differ much from traditional prosthetics. At the present stage, only laboratory experiments are carried out, mainly on rodents. When this method will work on a person, there are no exact forecasts.

It will take a few more years, perhaps even a dozen, before all the controversial issues of artificial cultivation will be resolved and this method will become available to any circle of patients.

To begin with, the technology of such cultivation must go through all animal experiments, after that there will be clinical trials on humans. If they justify themselves, then this technology will be put into practice.

Experience of centenarians

Despite the fact that artificial cultivation technology has not yet found its application in medicine, in modern practice there are already cases of people who have already managed to acquire a third set of teeth.

How could this happen? Mystic, nothing else! In the Russian town of Sochi lives a pensioner Tsapovalova, whose new teeth began to grow after the centennial anniversary. This amazing case made a splash in modern medicine. While experts thought and wondered how this happened, the pensioner herself revealed all the cards. According to the woman, this anomaly occurred as a result of her healthy lifestyle. She did not drink, did not smoke, was a vegetarian and tried to avoid stressful situations.

This case is not the only one of its kind. Four more centenarians were identified who were lucky enough to have a third set. One resident of the Indian outback, who was also a vegetarian, but he did not observe even the simplest hygiene. Centenarians from Tatarstan and Cheboksary can also boast of a third set of teeth.